Metabolis® 系統生物學代謝優化平台
Metabolis® Metabolic Optimization Platform
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解鎖代謝潛力，驅動生物創新
Unlocking Metabolic Potential for Bio-based Innovation
Metabolis® 是一個高度模組化的多組學路徑優化平台，旨在透過整合式工具，協助研發團隊解鎖代謝潛力，推動生技創新。其服務涵蓋多項核心工程功能，包含代謝流分配建構、酵素表現、動態調控及多層次回饋機制，以精準優化代謝路徑。平台提供全面的資料分析，從譜圖分析與註解，到功能富集分析，再到數據視覺化，協助研發團隊深入理解代謝機制，開發高價值代謝產物、優化生產菌株等生物技術領域的應用研究。
核心模组功能介绍
Introduction to core module functions
Metabolis® 調控平台提供一套高度模組化的多體學工程工具，核心功能涵蓋：
代謝流分配建構：針對關鍵中間代謝物導流設計，優化下游產物累積效率。
酵素表現動態調控：可依據代謝瓶頸設計調控元件組合，調整酵素合成速率。
多層次回饋機制建構：支援基於感應器、代謝訊號或環境參數的自我調節邏輯模組。
搭配模組視覺化設計介面與可調式參數設計器，協助使用者實現可預測的代謝工程方案。
Metabolis® 核心平台包含代謝流分配建構、酵素表現動態調控及多層次回饋機制，應用於多種設計情境，以下為常見模組組合策略
圖譜分析與註解
圖譜分析與註解
Spectral processing & Annotation
液相層析質譜（LC-MS）與氣相層析質譜（GC-MS）數據解讀。
涵蓋數據依賴採集（DDA）與數據非依賴採集（DIA）模式。
結合 HMDB、KEGG、MetaCyc 等資料庫 進行嚴謹的數據處理。
功能富集分析
功能富集分析
Functional Enrichment
代謝/蛋白組學數據分析，採用多重檢定修正與富集模型，確保結果可信度。
透過GO/KEGG分析提供全面且系統性的視角，深入理解實驗數據背後的生物學意義。
挖掘潛在靶點，加速藥物研發、疾病研究與代謝工程等應用。
數據視覺化
數據視覺化
Data Visualization
整合 KEGG、Reactome、MetaCyc 等國際資源。快速識別差異分子集中於哪些關鍵生物通路。
視覺化的網路圖、路徑圖與交互式可視化。重點標示在顯著變化的代謝物與反應節點。
應用場景：藥物研發、疾病研究、代謝工程。
｜代謝圖譜分析與註解服務
我們專注於基於液相層析質譜（LC-MS）與氣相層析質譜（GC-MS）平台的代謝圖譜分析與註解，涵蓋數據依賴採集（DDA）與數據非依賴採集（DIA）模式。透過嚴謹的數據處理流程與權威代謝資料庫（如 HMDB、KEGG、MetaCyc）的比對，我們能準確進行代謝物鑑定、定量分析與功能路徑關聯解析，協助客戶深入理解代謝變化機制，發掘潛在生物標誌物，並推動醫療、營養與生物技術領域的應用研究。
｜生物路徑富集分析服務
我們提供專業的生物路徑富集（Functional Enrichment）分析，協助客戶從基因體、轉錄體、蛋白體或代謝體數據中，精確定位顯著變化分子所涉及的關鍵生物通路。透過整合 KEGG、Reactome、MetaCyc 等國際標準資料庫與嚴謹的統計模型，我們能快速揭示分子網絡中的功能熱點，幫助研發團隊深入理解生物機制、挖掘潛在靶點，並加速藥物研發、疾病研究與代謝工程等應用。
｜代謝網路數據呈現
我們提供專業的代謝網路數據呈現（ Visualization）服務，將複雜的代謝體或多組學數據轉化為清晰易讀的網路圖與交互式可視化結果。透過結合 KEGG、MetaCyc 等資料庫的代謝路徑資訊與高效的圖形化演算法，我們可將代謝物、酶與路徑之間的關聯動態展示，並標示顯著變化的節點與反應。此服務可幫助研發團隊快速理解代謝系統全貌，識別關鍵調控節點，並支援藥物研發、疾病研究、代謝工程設計等多種應用。
Metabolis® is a highly modular Omics Pathway Optimization Platform that provides R&D teams with integrated tools to unlock metabolic potential and drive biotech innovation. It offers core engineering functions such as metabolic flux redistribution, dynamic enzyme expression control, and multi-layered feedback mechanisms for precise pathway optimization. The platform also delivers comprehensive data analysis services—from spectral analysis to functional enrichment and data visualization—to help researchers understand metabolic mechanisms. This enables the development of high-value products, optimization of production strains, and restructuring of metabolic pathways, enhancing yield and system efficiency in biotechnology.
｜Core Module Function Overview
The Metabolis® Regulation Platform offers a highly modular suite of metabolic engineering tools.
Its core features include:
Metabolic® Flux Redistribution: Design strategies for redirecting key intermediates to maximize product accumulation.
Dynamic Enzyme Expression Control: Build tunable regulatory combinations to adjust enzyme synthesis rates according to bottlenecks.
Multi-Layered Feedback Mechanisms: Support sensor-based, metabolic signal-based, or environmental condition-driven self-regulatory logic modules.
With a visual module designer and parameter-tuning interface, Metabolis enables predictive, efficient metabolic circuit construction.
｜Workflow & Service Integration
The Metabolis® Regulation Platform offers a one-stop service from design to implementation. Based on your research goals, you can select required modules and run strategy simulations. We support component selection, pathway planning, and validation of regulatory strategies, with optional extensions to wet-lab prototyping and system construction.
｜Spectral Analysis & Annotation
We specialize in metabolomic profiling and annotation based on liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS) platforms, supporting both data-dependent acquisition (DDA) and data-independent acquisition (DIA) modes. Through rigorous data processing workflows and matching against authoritative metabolic databases such as HMDB, KEGG, and MetaCyc, we provide accurate metabolite identification, quantitative analysis, and functional pathway association. Our service enables clients to gain deep insights into metabolic alterations, identify potential biomarkers, and advance applications in healthcare, nutrition, and biotechnology research.
｜Functional Enrichment
We provide professional Biological Pathway Enrichment analysis to help clients precisely identify key biological pathways associated with significantly altered molecules from genomics, transcriptomics, proteomics, or metabolomics data. By integrating internationally recognized databases such as KEGG, Reactome, and MetaCyc with rigorous statistical models, we rapidly uncover functional hotspots within molecular networks, enabling R&D teams to gain deeper insights into biological mechanisms, discover potential targets, and accelerate applications in drug development, disease research, and metabolic engineering.
｜Visualization
We offer professional Metabolic Network Data Visualization services, transforming complex metabolomics or multi-omics datasets into clear, interpretable network diagrams and interactive visualizations. By integrating metabolic pathway information from databases such as KEGG and MetaCyc with advanced graphing algorithms, we dynamically display the relationships among metabolites, enzymes, and pathways, highlighting significantly altered nodes and reactions. This service enables R&D teams to gain a holistic view of metabolic systems, pinpoint critical regulatory nodes, and support diverse applications in drug discovery, disease research, and metabolic engineering.
調控流向，打造高效率的微型工廠
Engineering efficient flow — build your next-gen microbial factory.
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